November 16, 2007, Newsletter Issue #53: Testicular Causes of Male Infertility

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Male infertility is a complex and challenging problem to overcome, since there are many contributing causes. Problems with the testicles can contribute to male infertility, with the main testicular causes of male infertility including:

Genetic disordersInternal disordersExternal conditionsSome genetic disorders which can contribute to male infertility include:

Kleinfelter's Syndrome - an extra "X" chromosome results in small testes with low sperm volume.XX Disorders - causes structural problems within the penis and variable sperm production.Noonan's Syndrome - low sperm production and abnormal testes, with testicle damage later in lifeEnzymatic production defects, including defective testosterone production and androgen resistanceInternal problems which can impair conception include:

Lack of testes or anorchia (pronounced "an-or-key-uh")Absence of sperm germinal cells - cells which mature into functional spermBlocked ducts leading from the testes to the penisSystemic diseases such as kidney failure, liver failure and sickle cell diseaseScrotal cysts or fluid pouches, called varicoceles (pronounced "var-ick-oh-seals")Overheating of testicles due to backflow of blood into the scrotumExternal contributors to male infertility related to the testicles, include:

Radiation for cancer treatmentTesticular trauma, such as that caused by straddle injuriesAcquired infections such as mumps and sexually transmitted diseasesInjuries associated with surgery in the groin, bowel, or pelvisAs with the other causes and contributors to male infertility, there are many conditions which negatively affect the ability to produce children. Talk to your Infertility Specialist about testicular causes which may be impacting your ability to conceive.

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